Bacterial topoisomerase inhibitors represent a promising class of antimicrobial agents that target essential enzymes involved in DNA replication and maintenance. By inhibiting enzymes such as DNA ...

Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...

Bacterial chromosome dynamics and gene regulation are intimately linked through a finely orchestrated interplay between the physical organization of the chromosome and the molecular processes that ...

Transposons are critical drivers of bacterial evolution that have been studied for many decades and have been the subject of Nobel Prize winning research. Now, researchers from Cornell University have ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

Deep in coastal mangroves and even inside our own mouths, biologists are finding that DNA does not always sit in a simple ...

As antibiotic-resistant infections rise and are projected to cause up to 10 million deaths per year by 2050, scientists are looking to bacteriophages, viruses that infect bacteria, as an alternative.

As the number of antibiotic-resistant infections continues to rise, scientists are looking to bacteriophages (“phages”), viruses that infect bacteria, as an approach to tackling antibiotic resistance.

Two bacteria are sitting near free-floating DNA. Suddenly, one bacterium shoots out a long appendage, latches onto a DNA fragment and reels in its catch. It happens fast, but it’s clear: this organism ...

Discover how a tiny RNA molecule serves as a molecular switch in viral infections, providing insights into phage biology.