The complement system is a critical modulator of immune responses that triages microbial and other threats through pattern recognition, tailored effector functions, and intensive crosstalk with other ...

The complement system is necessary for the induction of optimal T-cell effector function. In complement component 3 (C3)-deficient mice, CD4 + T-cell responses to viruses are impaired and the optimal ...

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven ...