A chemogenomic library is a collection of well-defined pharmacological agents. A hit from such a set in a phenotypic screen suggests that the annotated target or targets of the probe molecules are ...

Figure 1: Approaches to genetic perturbation: shRNA knockdown, Cas9 knockout, and dCas9 transcriptional activation. Table 1 Previously published screens using Cas9. Full size table Here we explain in ...

George Church and Colleagues Provide an Elegant Solution to the Problem Being able to derive screening data from very large-scale experiments without the need to test every interacting pair separately ...