This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

在生命科学的领域，DNA曾被誉为生命的“天书”，承载了生物体所有的遗传信息。然而，如何解读这本“天书”，从中提取关键的生物学信息，一直是科学界面临的巨大挑战。从基因表达到增强子活性，再到与疾病相关的遗传变异，这些复杂的分子表型背后隐藏 ...

Nucleotides are essential components of a wide range of cellular processes; therefore, the maintenance of these levels through various metabolic pathways is crucial for adequate cellular function. The ...