食管鳞癌（ESCC）占食管癌90%，早期治疗依赖内镜切除，但复发率高，缺乏特异靶向药物。液-液相分离（LLPS）在肿瘤中的作用日益受关注，但与ESCC关系不明。

得益于雷根斯堡在RNA生物学方面的专业知识、其独特的菌株库以及在培养嗜极古菌方面的专门技术，这项新技术被证明特别有效。因此，在本研究中，能够使用到最适生长温度高达113°C的超嗜热古菌世界纪录保持者。

总的来说，这项研究提供了大脑皮层中大量的 lncRNA 和 circRNA 及其相应的顺式表达数量性状基因座（cis-eQTL），这有助于更深入地理解大脑皮层中基因表达的遗传调控，并弥合大脑相关疾病遗传关联与其病理生理机制之间的差距。

RNA sequence design and inverse folding constitute pivotal areas in computational biology, aiming to identify nucleotide sequences that adopt predetermined structural conformations. The inverse ...

本研究针对血吸虫病治疗药物单一、耐药性风险高等问题，系统开展了非寄生虫基因组编码RNA (ngRNA)在日本血吸虫 (S.japonicum)致病性调控中的作用研究。研究人员通过宏转录组学、单细胞RNA测序等技术，首次发现4种ngRNA通过编码RNA依赖性RNA聚合酶 (RdRp)调控血吸虫卵巢发育和产卵过程，并证实靶向rp1 ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 4 (January 25, 2022), pp. 1-11 (11 pages) RNA is a ubiquitous biomolecule that can serve as both catalyst ...

UC Vice President for Research Patrick Limbach is a key figure in the National Academies’ massive undertaking to sequence RNA in the next 15 years. A chemist who leads the University of Cincinnati’s ...

An individual’s genome is identifiable. But datasets of RNA sequences from single cells are like a blurry photocopy of the genome. The sequence numbers are small, the data are noisy, and the sequences ...

Discover how AI is revolutionizing RNA drug development in a new article published in Engineering. Learn about the potential ...

Scientists have sequenced RNA from a nearly 40,000-year-old woolly mammoth leg, the oldest ancient RNA ever recovered. These fragile molecules could reveal which genes were active in the animal’s ...

Bayosthiti AI Pvt Ltd. aims to make RNA sequencing and AI-based preventive health care affordable and accessible for the ...