Acquired resistance to HER2-targeted therapies occurs frequently in HER2 + breast tumors and new strategies for overcoming resistance are needed. Here, we report that resistance to trastuzumab is ...

Author's Affiliation: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York Corresponding Author: Ting-Chao Chou, Preclinical Pharmacology Core ...

Prostate cancer is the second leading cause of cancer-related death among American men. Most patients with prostate cancer present with castration-sensitive prostate cancer (CSPC) for whom initial ...

State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, P.R. China.

American Association for Cancer Research.

The evolutionarily conserved Hedgehog (HH) signaling pathway plays critical roles in embryonic patterning and adult tissue homeostasis (1, 2). Hyperactive HH signaling has been linked to a range of ...

A computational approach shows cryptic peptides as an abundant class of epitopes in different tumor samples. This approach can potentially be used to elucidate complete HLA-I immunopeptidomes and aid ...

AbstractDiffuse intrinsic pontine glioma (DIPG) is an invariably fatal brain tumor occurring predominantly in children. Up to 90% of pediatric DIPGs harbor a somatic heterozygous mutation resulting in ...

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Cancer Res (2023) 83 (8_Supplement): LB031.