Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

From an R&D standpoint, we believe that this is an important confirmation of the performance of the PL-14 formulation using a rigorous quanttative permeation model. The data support continued ...